Ziv Peremen, CEO of Xtrodes: An innovator in wearable sleep monitoring technology

X-trodes has developed the first customizable and wireless wearable technology to bring advanced medical-grade sleep monitoring and analysis to the convenience of patients’ homes. While other companies in the industry focus primarily on sleep apnea, X-trodes’ easy-to-use solution monitors patients for a wide range of sleep disorders, allowing for a significant reduction in diagnosis time and cost compared to traditional sleep assessments.

DocWire News sat down with the company’s CEO, Ziv Pereman, to learn more about this innovative company and its technologies.

DocWire News: Can you tell us something about yourself and the company X-trodes you founded?

Secure. First of all, thank you for giving me this opportunity today. I’m Ziv Peremen, the CEO and co-founder of X-trodes. I actually started my journey with physics and philosophy and then went on to do a PhD in neurocognitive science. And for the past 12 years, I’ve focused on the interaction between data and physiology. I am looking forward.

In the beginning it was just the brain, data for brain and I expanded. And as the years have gone by there have been more and more parts of our bodies that I’m interested in and the current journey of X-trodes actually started a few years ago. I met an amazing professor, Yael Hanein. She was formerly the head of the nanotechnology center at Tel Aviv University. She’s a global expert in human-machine interface and I asked her if she could come up with a solution for all of these cumbersome devices we need to map our brains.

It took her five years, but when she came up with the solution, she was so elegant, so beautiful, and we both decided something big was going on here. And we decided to found X-trodes. So we started X-trodes three years ago and we’ve been on this exciting journey together ever since.

Talk to us about the importance of understanding sleep behavior and the challenges of traditional sleep analysis and diagnostic solutions.

sleep is important. Actually, it’s super important. Most of us spend almost a third of our lives asleep. And unfortunately, more than 40% of the population actually suffer from insomnia. And we can say, okay, bad sleep. It affects our quality of life. We have a rough day after a bad night, but it’s not just about quality of life. So much happens during sleep that affects our brain, cognition, immune system and health. And once we begin to understand that sleep is not a luxury. In a way, sleep is key to our health.

Once we start to understand it and it seems that the clinical society and science is starting to understand the importance of sleep. For many years, but this term has been increasing in the last three years. We’re beginning to understand that all of those 40% I mentioned earlier suffer from poor sleep. This has a huge impact on their daily life and health. And when we start to see what we can do with health. So most of us are familiar with taking sleeping pills, but that’s not enough. There are so many aspects of our sleep that can be compromised, altered or carried over over time, as we age, in our life stage. And without understanding what’s going on throughout our health, we have poor tools to properly manage it.

So I will say that sleep is a key to our quality of life, well-being and health. And I think we understand that for sleep, too, we need a better diagnosis than we have today. And how we can measure sleep today, I think most of you are familiar with sleep studies. So this is the medical solution to measure sleep. I’ll come back to that, it’s called PSD, polysomnography. But we see that we as consumers have more and more tools at our disposal. We are familiar with rings, watches, mattresses and many other solutions. But all of these solutions are wellness solutions. They don’t give you the medical information you need to get a true diagnosis of your sleep.

We have another group, very good and very successful group of tools to measure your sleep at home, mainly for sleep apnea. To measure your snoring and all kinds of breathing problems. These are very good tools. However, they focus on one or two glitches. Today there are more than 40 different sleep disorders. And you can double the number if you also link it to other clinical disorders related to sleep. In addition to the wellness solution and the sleep apnea solutions, today you have to go to the clinic to have a sleep study carried out. You have to go to the hospital, spend the night in the hospital, hooked up to the 30 electrodes, actually sleep in someone else’s bed. Those are the golden standards we have today.

I would say for myself I was shocked by the numbers I was told that on this test more than 30% of these tests actually fail. So you go to the hospital or take your child to the hospital, you spend the night there. And after all that activity, all that effort, and the kid couldn’t fall asleep in the hospital, or he was moving too much because it’s not his bed. And you don’t get the result after so much effort. So we understand that today there is a real need to find a way to measure it. Not at home in the hospital. Not a single night, several nights. To make our sleep mapping accessible to all of us. That’s what we miss in our sleep today.

What solution does X-trodes offer for sleeping problems?

We have developed a unique solution. We call it smart. Smart Skin are actually several sensors that we can attach to our skin. It’s like a band-aid and measures our body’s electrophysiological signals. And our body creates an electrical signal from our brain, from our muscles, from our heart, from our eyes. And with this Smart Skin, we actually measure all this information from your skin. So our solution consists of these unique sensors that make it possible to measure our skin and algorithms that allow us to reduce the noise that we have in the home environment.

You have all kinds of noise, electrical noise from your phone, from the outlet, from your partner around you. So the solution of this unique sensor on the one hand and the unique algorithms give us a solution that was not available until today. I hope you can see it. This is an example of one of our sensors. It’s a dry sensor. Unlike the hospitals that need all kinds of gels or paste to stick it on the skin, this is our sensor. It’s like a band-aid and when I take it out you’ll see how flexible and stretchy it is. It is actually more flexible and softer than our skin.

So let’s attach it to our skin, as you can see here we can attach it to the skin. I connect it to a small device with electronic battery and bluetooth device. See it here. And that’s it. Once I have the signal with me, I have connected the sensor to my body, we can receive the signals on another device, either a tablet or a phone. So basically these simple electrodes that I can locate on our head, on our hand, on our chest replace all of the electrodes and cumbersome devices that we know from sleep research today.

This solution allows us to connect them to patients and healthy participants to measure sleep, brain activity, heart activity, muscle activity and generate all this information remotely for the doctor. And they can measure it for a day, two, three days, a week. In fact, not only can you use it to diagnose, you can start some kind of treatment to see if your sleep has improved. They can change all kinds of feel-good parameters in life. They can change their diet, exercise to see if sleep has actually improved.

They had a device to take home to measure long-term, medical-grade sleep. It’s not a short-term measurement, it’s a whole night, several nights. At home with full availability for this device and data access for the doctor. This is our solution, which we call Smart Sleep.

What other areas of application are there for the technology?

X-trodes offers a platform. It’s a unique platform to measure electrophysiology, all the signals I mentioned before, brain, muscle and heart activity, and bring them into the natural environment. We take this super sensitive sensor that is being measured in hospitals today in very controlled areas and very isolated rooms. And we’re taking it to the noisiest environment imaginable, our home, to get away from our natural surroundings. So this is where we are headed, this is where we plan to launch our platform.

Today in the healthcare system we have identified more than 100 different applications that are used today. Electrophysiology tools in the hospitals. Our goal is to bring solutions to this application, or at least most of them, and make them accessible for home use as well. So we can think of all kinds of applications. Sleep is our first application. We can also talk about muscle measurement. With this electrode surface EMG, we can measure muscle fatigue synchronization and shorten the rehabilitation process after injury. For example knee or back injuries or after operations.

We can also provide notifications for an athlete when using it when the muscle reaches a certain threshold it increases the risk of injury. But there are so many other uses of it. It could be relevant to epilepsy. Today, patients spend days, a week, in the hospital to monitor the epileptic seizures. We have a solution for home use. Nowadays there are people who use all kinds of holsters with cords and all other cumbersome devices to measure their heart that can provide the solution to this.

There are so many uses that we can use it for health, and I think it goes even beyond health. I’m not sure if ‘beyond health’ would be the right term, but we understand that the world has changed, especially post COVID. And you try to find solutions to prevent the next disruption. To treat them, to keep them healthy. So I think we can use the tool for the current diseases that we have in the hospitals today. But I also think that this tool could help us in areas that we call wellness or between health and wellness, prevention. To keep us all in better shape, to improve our quality of life and awareness. So I think there is huge potential for such a technology in many applications.



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